Goethe already dealt with the topic in detail and even created illustrations that are supposed to show how so-called "color-blind people" - today we use the term color vision deficiency or impaired color vision - see colors. In the second half of the 19th century, in the course of the increased volume of traffic during industrialization, there were some serious rail and ship accidents, the cause of which was identified as the confusion of the colored signal lights. This led to a veritable boom in research into color blindness and the development of methods to detect it, which show an astonishing variety.